50 TOP CHOLINOMIMETIC DRUGS Multiple Choice Questions and Answers pdf

CHOLINOMIMETIC DRUGS Multiple Choice Questions and Answers pdf :-

1. Acetylcholine is not a specific neurotransmitter at:
a) Sympathetic ganglia
b) Sympathetic postganglionic nerve endings
c) Parasympathetic ganglia
d) Parasympathetic postganglionic nerve endings

2. Muscarinic receptors are located in:
a) Autonomic ganglia
b) Skeletal muscle neuromuscular junctions
c) Autonomic effector cells
d) Sensory carotid sinus baroreceptor zone

3. Indicate the location of M2 cholinoreceptor type:
a) Heart
b) Glands
c) Smooth muscle
d) Endothelium

4. The symptoms of mushroom poisoning include all of the following EXCEPT:
a) Salivation, lacrimation, nausea, vomiting
b) Dryness of mouth, hyperpyrexia, hallucination
c) Headache, abdominal colic
d) Bradycardia, hypotension and shock

5. Which of the following cholinomimetics activates both muscarinic and nicotinic receptors?
a) Lobeline
b) Pilocarpine
c) Nicotine
d) Bethanechol

6. Indicate a cholinomimetic agent, which is related to direct-acting drugs:
a) Edrophonium
b) Physostigmine
c) Carbachol
d) Isoflurophate

7. Characteristics of carbachol include all of the following EXCEPT:
a) It decreases intraocular pressure
b) It causes mydriasis
c) It exerts both nicotinic and muscarinic effects
d) It is resistant to acethylcholiesterase

8. Acetylcholine is not used in clinical practice because:
a) It is very toxic
b) The doses required are very high
c) It is very rapidly hydrolyzed
d) It is very costly

9. Parasympathomimetic drugs cause:
a) Bronchodilation
b) Mydriasis
c) Bradycardia
d) Constipation

10. Which of the following direct-acting cholinomimetics is mainly muscarinic in action?
a) Bethanechol
b) Carbachol
c) Acetylcholine
d) None of the above

11. Which of the following direct-acting cholinomimetics has the shortest duration of action?
a) Acetylcholine
b) Methacholine
c) Carbachol
d) Bethanechol

12. Bethanechol has all of the following properties EXCEPT:
a) It is extremely resistant to hydrolysis
b) Purely muscarinic in its action
c) It is used for abdominal urinary bladder distention
d) It exerts both nicotinic and muscarinic effects

13. A M-cholinimimetic agent is:
a) Carbachol
b) Pilocarpine
c) Acetylcholine
d) Bethanechol

14. Characteristics of pilocarpine include all of the following EXCEPT:
a) It is a tertiary amine alkaloid
b) It causes miosis and a decrease in intraocular pressure
c) Causes a decrease in secretory and motor activity of gut
d) It is useful in the treatment of glaucoma

15. Which of the following cholinomimetics is a plant derivative with lower potency than nicotine but with a similar spectrum of action?
a) Lobeline
b) Pilocarpine
c) Carbochol
d) Acetylcholine

16. Which of the following cholinomimetics is indirect-acting?
a) Lobeline
b) Edrophonium
c) Pilocarpine
d) Carbachol

17. The mechanism of action of indirect-acting cholinomimetic agents is:
a) Binding to and activation of muscarinic or nicotinic receptors
b) Inhibition of the hydrolysis of endogenous acetylcholine
c) Stimulation of the action of acetylcholinesterase
d) Releasing acetylcholine from storage sites

18. Indicate a reversible cholinesterase inhibitor:
a) Isoflurophate
b) Carbochol
c) Physostigmine
d) Parathion

19. Which of the following cholinesterase inhibitors is irreversible?
a) Physostigmine
b) Edrophonium
c) Neostigmine
d) Isoflurophate

20. Indicate cholinesterase activator:
a) Pralidoxime
b) Edrophonium
c) Pilocarpine
d) Isoflurophate

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21. Isofluorophate increases all of the following effects except:
a) Lacrimation
b) Bronchodilation
c) Muscle twitching
d) Salivation

22. Indicate a cholinesterase inhibitor, which has an additional direct nicotinic agonist effect:
a) Edrophonium
b) Carbochol
c) Neostigmine
d) Lobeline

23. Сholinesterase inhibitors do not produce:
a) Bradycardia, no change or modest fall in blood pressure
b) Increased strength of muscle contraction, especially in muscles weakened by myasthenia gravis
c) Miosis and reduction of intraocular pressure
d) Dramatic hypertension and tachycardia

24. Which of the following cholinomimetics is commonly used in the treatment of glaucoma?
a) Pilocarpine
b) Lobeline
c) Acethylcholine
d) Neostigmine

25. Indicate the organophosphate cholinesterase inhibitor, which can be made up in an aqueous solution for ophthalmic use and retains its activity within a week:
a) Physoctigmine
b) Edrophonium
c) Echothiophate
d) Neostigmine

26. Which of the following cholinomimetics is most widely used for paralytic ileus and atony of the urinary bladder?
a) Lobeline
b) Neostigmine
c) Pilocarpine
d) Echothiophate

27. Chronic long-term therapy of myasthenia is usually accomplished with:
a) Edrophonium
b) Neostigmine
c) Echothiophate
d) Carbachol

28. Which of the following cholinomimetics is a drug of choice for reversing the effects of nondepolarizing neuromuscular relaxants?
a) Echothiophate
b) Physostigmine
c) Edrophonium
d) Pilocarpine

29. Indicate the reversible cholinesterase inhibitor, which penetrates the blood-brain barrier:
a) Physostigmine
b) Edrophonium
c) Neostigmine
d) Piridostigmine

30. Which of the following cholinomimetics is used in the treatment of atropine intoxication?
a) Neostigmine
b) Carbochol
c) Physostigmine
d) Lobeline

31. The symptoms of excessive stimulation of muscarinic receptors include all of the following EXCEPT:
a) Abdominal cramps, diarrhea
b) Increased salivation, excessive bronchial secretion
c) Miosis, bradycardia
d) Weakness of all skeletal muscles

32. The excessive stimulation of muscarinic receptors by pilocarpine and choline esters is blocked competitively by:
a) Edrophonium
b) Atropine
c) Pralidoxime
d) Echothiophate

33. The toxic effects of a large dose of nicotine include all of the following EXCEPT:
a) Hypotension and bradycardia
b) Convulsions, coma and respiratory arrest
c) Skeletal muscle depolarization blockade and respiratory paralysis
d) Hypertension and cardiac arrhythmias

34. The dominant initial sights of acute cholinesterase inhibitors intoxication include all of the following except:
a) Salivation, sweating
b) Mydriasis
c) Bronchial constriction
d) Vomiting and diarrhea

35. Which of the following drugs is used for acute toxic effects of organophosphate cholinesterase inhibitors?
a) Atropine
b) Pilocarpine
c) Pralidoxime
d) Edrophonium

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