70 TOP ADRENORECEPTOR ACTIVATING DRUGS Multiple Choice Questions and Answers pdf

ADRENORECEPTOR ACTIVATING DRUGS Multiple Choice Questions and Answers pdf :-

1. Sympathetic stimulation is mediated by:
a) Release of norepinephrine from nerve terminals
b) Activation of adrenoreceptors on postsynaptic sites
c) Release of epinephrine from the adrenal medulla
d) All of the above

2. Characteristics of epinephrine include all of the following EXCEPT:
a) It is synthesized into the adrenal medulla
b) It is synthesized into the nerve ending
c) It is transported in the blood to target tissues
d) It directly interacts with and activates adrenoreceptors

3. Which of the following sympathomimetics acts indirectly?
a) Epinephrine
b) Norepinephrine
c) Ephedrine
d) Methoxamine

4. Indirect action includes all of the following properties EXCEPT:
a) Displacement of stored catecholamines from the adrenergic nerve ending
b) Inhibition of reuptake of catecholamines already released
c) Interaction with adrenoreceptors
d) Inhibition of the release of endogenous catecholamines from peripheral adrenergic neurons

5. Catecholamine includes following EXCEPT:
a) Ephedrine
b) Epinephrine
c) Isoprenaline
d) Norepinephrine

6. Epinephrine decreases intracellular camp levels by acting on:
a) α1 receptor
b) α2 receptor
c) beta1 receptor
d) beta2 receptor

7. Which of the following statements is not correct?
a) ALFA receptors increase arterial resistence, whereas beta2 receptor promote smooth muscle relaxation
b) The skin and splanchic vessels have predominantly alfa receptors
c) Vessels in a skeletal muscle may constrict or dilate depending on whether alfa or beta2 receptors are activated
d) Skeletal muscle vessels have predominantly alfa receptors and constrict in the presence of epinephrine and
norepinephrine

8. Direct effects on the heart are determined largely by:
a) Alfa1 receptor
b) Alfa2 receptor
c) Beta1 receptor
d) Beta2 receptor

9. Which of the following effects is related to direct beta1-adrenoreceptor stimulation?
a) Bronchodilation
b) Vasodilatation
c) Tachycardia
d) Bradycardia

10. Distribution of alfa adrenoreceptor subtypes is associated with all of the following tissues except those of:
a) Heart
b) Blood vessels
c) Prostate
d) Pupillary dilator muscle

11. Beta adrenoreceptor subtypes is contained in all of the following tissues EXCEPT:
a) Bronchial muscles
b) Heart
c) Pupillary dilator muscle
d) Fat cells

12. In which of the following tissues both alfa and beta1 adrenergic stimulation produces the same effect?
a) Blood vessels
b) Intestine
c) Uterus
d) Bronchial muscles

13. The effects of sympathomimetics on blood pressure are associated with their effects on:
a) The heart
b) The peripheral resistance
c) The venous return
d) All of the above

14. A relatively pure alfa agonist causes all of the following effects EXCEPT:
a) Increase peripheral arterial resistance
b) Increase venous return
c) Has no effect on blood vessels
d) Reflex bradycardia

15. A nonselective beta receptor agonist causes all of the following effects EXCEPT:
a) Increase cardiac output
b) Increase peripheral arterial resistance
c) Decrease peripheral arterial resistance
d) Decrease the mean pressure

16. Which of the following statement is not correct?
a) Αlfa agonists cause miosis
b) Αlfa agonists cause mydriasis
c) Beta antagonists decrease the production of aqueous humor
d) Αlfa agonists increase the outflow of aqueous humor from the eye

17. A bronchial smooth muscle contains:
a) Αlfa1 receptor
b) Αlfa2 receptor
c) Beta 1 receptor
d) Beta 2 receptor

18. All of the following agents are beta receptor agonists EXCEPT:
a) Epinephrine
b) Isoproterenol
c) Methoxamine
d) Dobutamine

19. Which of the following drugs causes bronchodilation without significant cardiac stimulation?
a) Isoprenaline
b) Terbutaline
c) Xylometazoline
d) Methoxamine

20. Αlfa-receptor stimulation includes all of the following effects EXCEPT:
a) Relaxation of gastrointestinal smooth muscle
b) Contraction of bladder base, uterus and prostate
c) Stimulation of insulin secretion
d) Stimulation of platelet aggregation

21. Beta1 receptor stimulation includes all of the following effects EXCEPT:
a) Increase in contractility
b) Bronchodilation
c) Tachycardia
d) Increase in conduction velocity in the atrioventricular node

22. Beta2 receptor stimulation includes all of the following effects EXCEPT:
a) Stimulation of renin secretion
b) Fall of potassium concentration in plasma
c) Relaxation of bladder, uterus
d) Tachycardia

23. Hyperglycemia induced by epinephrine is due to:
a) Gluconeogenesis (beta2)
b) Inhibition of insulin secretion (alfa)
c) Stimulation of glycogenolysis (beta2)
d) All of the above

24. Which of the following effects is associated with beta3-receptor stimulation?
a) Lipolysis
b) Decrease in platelet aggregation
c) Bronchodilation
d) Tachycardia

25. Which of the following statements is not correct?
a) Epinephrine acts on both alfa- and beta-receptors
b) Norepinephrine has a predominantly beta action
c) Methoxamine has a predominantly alfa action
d) Isoprenaline has a predominantly beta action

26. Indicate the drug, which is a direct-acting both alfa- and beta-receptor agonist:
a) Norepinephrine
b) Methoxamine
c) Isoproterenol
d) Ephedrine

27. Which of the following agents is an alfa1 alfa2 beta1 beta2 receptor agonist?
a) Methoxamine
b) Albuterol
c) Epinephrine
d) Norepinephrine

28. Indicate the direct-acting sympathomimetic, which is an alfa1 alfa2 beta1 receptor agonist:
a) Isoproterenol
b) Ephedrine
c) Dobutamine
d) Norepinephrine

29. Which of the following agents is an alfa1-selective agonist?
a) Norepinephrine
b) Methoxamine
c) Ritodrine
d) Ephedrine

30. Indicate the alfa2-selective agonist:
a) Xylometazoline
b) Epinephrine
c) Dobutamine
d) Methoxamine

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31. Which of the following agents is a nonselective beta receptor agonist?
a) Norepinephrine
b) Terbutaline
c) Isoproterenol
d) Dobutamine

32. Indicate the beta1-selective agonist:
a) Isoproterenol
b) Dobutamine
c) Metaproterenol
d) Epinephrine

33. Which of the following sympathomimetics is a beta2-selective agonist?
a) Terbutaline
b) Xylometazoline
c) Isoproterenol
d) Dobutamine

34. Indicate the indirect-acting sympathomimetic agent:
a) Epinephrine
b) Phenylephrine
c) Ephedrine
d) Isoproterenol

35. Epinephrine produces all of the following effects EXCEPT:
a) Positive inotropic and chronotropic actions on the heart (beta1 receptor)
b) Increase peripheral resistance (alfa receptor)
c) Predominance of alfa effects at low concentration
d) Skeletal muscle blood vessel dilatation (beta2 receptor)

36. Epinephrine produces all of the following effects EXCEPT:
a) Decrease in oxygen consumption
b) Bronchodilation
c) Hyperglycemia
d) Mydriasis

37. Epinephrine is used in the treatment of all of the following disorders EXCEPT:
a) Bronchospasm
b) Anaphylactic shock
c) Cardiac arrhythmias
d) Open-angle glaucoma

38. Compared with epinephrine, norepinephrine produces all of the following effects EXCEPT:
a) Similar effects on beta1 receptors in the heart and similar potency at an alfa receptor
b) Decrease the mean pressure below normal before returning to the control value
c) Significant tissue necrosis if injected subcutaneously
d) Increase both diastolic and systolic blood pressure

39. Norepinephrine produces:
a) Vasoconstriction
b) Vasodilatation
c) Bronchodilation
d) Decresed potassium concentration in the plasma

40. Which of the following direct-acting drugs is a relatively pure alfa agonist, an effective mydriatic and decongestant and
can be used to raise blood pressure?
a) Epinephrine
b) Norepinephrine
c) Phenylephrine
d) Ephedrine

41. Characteristics of methoxamine include all of the following EXCEPT:
a) It is a direct-acting alfa1-receptor agonist
b) It increases heart rate, contractility and cardiac output
c) It causes reflex bradycardia
d) It increases total peripheral resistance

42. Which of the following agents is an alfa2-selective agonist with ability to promote constriction of the nasal mucosa?
a) Xylometazoline
b) Phenylephrine
c) Methoxamine
d) Epinephrine

43. Indicate the sympathomimetic, which may cause hypotension, presumably because of a clonidine-like effect:
a) Methoxamine
b) Phenylephrine
c) Xylometazoline
d) Isoproterenol

44. Isoproterenol is:
a) Both an alfa- and beta-receptor agonist
b) beta1-selective agonist
c) beta2-selective agonist
d) Nonselective beta receptor agonist

45. Isoproterenol produces all of the following effects EXCEPT:
a) Increase in cardiac output
b) Fall in diastolic and mean arterial pressure
c) Bronchoconstriction
d) Tachycardia

46. Characteristics of dobutamine include all of the following EXCEPT:
a) It is a relatively beta1-selective synthetic catecholamine
b) It is used to treat bronchospasm
c) It increases atrioventricular conduction
d) It causes minimal changes in heart rate and systolic pressure

47. Characteristics of salmeterol include all of the following EXCEPT:
a) It is a potent selective beta2 agonist
b) It causes uterine relaxation
c) It stimulates heart rate, contractility and cardiac output
d) It is used in the therapy of asthma

48. Characteristics of ephedrine include all of the following EXCEPT:
a) It acts primarily through the release of stored cathecholamines
b) It is a mild CNS stimulant
c) It causes tachyphylaxis with repeated administration
d) It decreases arterial pressure

49. Ephedrine causes:
a) Miosis
b) Bronchodilation
c) Hypotension
d) Bradycardia

50. Compared with epinephrine, ephedrine produces all of the following features EXCEPT:
a) It is a direct-acting sympathomimetic
b) It has oral activity
c) It is resistant to MAO and has much longer duration of action
d) Its effects are similar, but it is less potent

51. Which of the following sympathomimetics is preferable for the treatment of chronic orthostatic hypotension?
a) Epinephrine
b) Norepinephrine
c) Ephedrine
d) Salmeterol

52. Indicate the sympathomimetic drug, which is used in a hypotensive emergency:
a) Xylometazoline
b) Ephedrine
c) Terbutaline
d) Phenylephrine

53. Which of the following sympathomimetics is preferable for the emergency therapy of cardiogenic shock?
a) Epinephrine
b) Dobutamine
c) Isoproterenol
d) Methoxamine

54. Indicate the sympathomimetic agent, which is combined with a local anesthetic to prolong the duration of infiltration
nerve block:
a) Epinephrine
b) Xylometazoline
c) Isoproterenol
d) Dobutamine

55. Which of the following sympathomimetics is related to short-acting topical decongestant agents?
a) Xylometazoline
b) Terbutaline
c) Phenylephrine
d) Norepinephrine

56. Indicate the long-acting topical decongestant agents:
a) Epinephrine
b) Norepinephrine
c) Phenylephrine
d) Xylometazoline

57. Which of the following topical decongestant agents is an alfa2-selective agonist?
a) Phenylephrine
b) Xylometazoline
c) Ephedrine
d) Epinephrine

58. Indicate the sympathomimetic, which may be useful in the emergency management of cardiac arrest:
a) Methoxamine
b) Phenylephrine
c) Epinephrine
d) Xylometazoline

59. Which of the following sympathomimetics is used in the therapy of bronchial asthma?
a) Formoterol
b) Norepinephrine
c) Methoxamine
d) Dobutamine

60. Indicate the agent of choice in the emergency therapy of anaphylactic shock:
a) Methoxamine
b) Terbutaline
c) Norepinephrine
d) Epinephrine

61. Which of the following sympathomimetics is an effective mydriatic?
a) Salmeterol
b) Phenylephrine
c) Dobutamine
d) Norepinephrine

62. The adverse effects of sympathomimetics include all of the following EXCEPT:
a) Drug-induced parkinsonism
b) Cerebral hemorrhage or pulmonary edema
c) Myocardial infarction
d) Ventricular arrhythmias

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